|Technical Gut Research|
|Phytochemical research – Polyphenols offer the building blocks to repair and maintain gut health. The Grazix team has created stable polyphenol-oxidant complexes that mimic intact plant cells and use enzymes naturally present in the gut to target bioactivity that may provide immunologic benefits.
Bacterial toxins bind to epithelial cell receptors causing a release of cytokines into the mucous membrane of the intestines. This activates sensory neurons which stimulate immune cells to the region—thus, causing inflammation. Polyphenols have been shown to inhibit these toxins and also act as non-specific endocrine receptors to reduce the immune response and enable rapid resolution of symptoms such as diarrhea, digestive spasms, and inflammation.
“Digestion of viable plant cells rich in polyphenols includes a rich source of reactive oxygen species (ROS), oxygen ions and peroxides produced and stored in plant cytoplasm. Phytobiologics deliver a stable, rich source of this polyphenol-ROS immune augmenting duo. In plant cells, production and presence of ROS has direct antimicrobial actions, such as strengthening host cell walls through cross-linking of glycoproteins, lipid peroxidation and membrane damage and inducing intracellular signaling pathways that mediate the activation of defense genes. Since the receptors on the plasma membrane of plants that recognize pathogens are similar to components found in the innate immune system of animals, there may be downstream signaling components common to both.”
Clinical and experimental studies demonstrate that defects in the intestinal tight junction barrier and increased permeability are observed in various intestinal and systemic diseases. Intestinal tight junction barrier is dynamically regulated by cytokines and pathogens, therefore, understanding the molecular mechanisms can lead to preventive therapeutic approaches.
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